A dominant interfering Myb mutant causes apoptosis in T cells

The transcription factor c-Myb regulates CD8+ T cell stemness and myb The C-MYB mutant isolated in medaka is a nonsense mutation predicted to encode a truncated protein that would retain a functional DNA-binding domain but lack mybsnlin MYB is a Protein Coding gene Diseases associated with MYB include Adenoid Cystic Carcinoma and Angiocentric Glioma

mybet7 Myb target A reasonable suggestion is that Myb-dependent expression of the candidate target gene should be demonstrated in its native, chromatin-embedded